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Larry I Good

Larry I Good

Good Pharmaceutical Development Company, USA

Title: Serum derived bovine immunoglobulin in the treatment of gastrointestinal disease


Biography: Larry I Good


Serum derived bovine immunoglobulin was introduced as a medical food in the U.S. in 2013. Since then it has been studied in over 800 patients with a variety of gastrointestinal illnesses including diarrhea predominant irritable bowel syndrome (IBS-D), ulcerative colitis, Crohn’s disease, pouchitis, C. difficile colitis and chronic mesenteric ischemia. Its effectiveness in these diverse disease entities is related to the ability of SBI to bind intraluminal pro-inflammatory mediators including enterotoxins, pro-inflammatory cytokines and bacterial degradation products, thereby, preventing the loss of intercellular tight junction proteins. By maintaining tight junction, integrity, dendritic antigenic stimulation in the mucosa is reduced, resulting in inhibition of the inflammatory cascade.           This presentation will review the US FDA category of medical foods, the proposed mechanism of action SBI and published clinical data.

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